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For many, a drug’s price seems to mirror the immense difficulty of creating life-saving therapies. Yet a closer look at the drug development landscape reveals a more nuanced picture—one where complex processes, regulatory frameworks, and layered profit incentives often play a significant role. Understanding these factors is essential to re-imagine how we approach affordability and…
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The recent news of layoffs at Aldevron has cast a shadow over the biotech community here in Fargo, but every winter has a spring and North Dakotans know this all too well. For those who have followed Aldevron’s journey from a tiny startup to a transformative force in the region, it’s difficult not to feel…
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The MAP Kinases are the most widely used eukaryotic cell signaling mechanism, and involve a cascade of kinase activity. This article covers the basic structure of MAPK pathways and provides context for the discussion of the three major human MAPKs (ERK, JNK, and p38).
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A Letter from the Editor – Introducing the Cell Signaling Series
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This overview of cell signaling provides the basis for the Cell Signaling Series special. It covers the use of signaling in the cell, the types of molecules involved, and some common pathways to be discussed in future articles.
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Deciding whether curiosity is a gift or a curse to humanity is a complicated endeavor. On one hand, our capacity for wonder, creativity, and problem-solving has transformed our species from a locally distributed band of primates into a planet-transforming group of toolbuilders and thinkers. On the other hand, it has produced a nearly unstoppable force…
Jeremy S. Houser 